Rening av bi- och multispecifika cancer-terapeutiska affinitets-proteiner och c-terminalt modifierade anti-HER3 affibodies för avbildningsdiagnostik / Purification of bi- and multispecific cancer therapeutic affinity proteins and c-terminally modified anti-HER3 affibody imaging agents

Description

Affibody molecules are small protein scaffolds that have been engineered to bind to a variety of targets with diversetherapeutic and diagnostic applications. In this study, an array of affibody containing therapeutic constructs,targeting HER2 and HER3, and diagnostic anti-HER3 imaging agents have been purified in preparation for subsequentcancer cell assays and imaging studies in tumour-bearing mice respectively. Herein, the workflow for severalpurification techniques is delineated.

Links & Downloads

1. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-190622

Tags

Affibody

protein therapeutic

cancer

HER3 medical imaging

tumor targeting

Other Biological Topics

Annan biologi

Additional Fields

Identifer	oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:kth-190622
Date	January 2016
Creators	Dahlsson Leitao, Charles
Publisher	KTH, Skolan för bioteknologi (BIO)
Source Sets	DiVA Archive at Upsalla University
Language	Swedish
Detected Language	English
Type	Student thesis, info:eu-repo/semantics/bachelorThesis, text
Format	application/pdf
Rights	info:eu-repo/semantics/openAccess