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Synthesis of novel benzimidazole derivatives and their platinum (II) complexes.

Imidazo[1,5-a]pyridines are an important and versatile class of N-heterocyclic compounds due

to their stability, unique biological, and photochemical properties. Due to the conjugation and

charged structure, their properties are extended to conducting electricity and also have

electronic properties. They can be used for chelating transition metals especially heavy metals that can be harmful to living things (including human).

The aim of this research was to develop more useful imidazo[1,5-a]pyridines which are stable in both free and complexed state. A variety of imidazo[1,5-a]pyridyl compounds was synthesized following three useful methods namely (i) The first route includes the isolation of

imine intermediates which were then treated with phosphorus oxychloride in one case and

hydrochloric acid in another case as catalysts. Both cases resulted in the yield of the same imidazo[1,5-a]pyridyl compounds. (ii) The second route was the development on the first route for those imine intermediates that could not be isolated and only hydrochloric acid

catalyst was used. In both the first and second routes, paraformaldehyde was used for the ringclosure step of the reaction. The last route for the formation of imidazo[1,5-a]pyridyl

compounds did not involve the use of the paraformaldehyde reagent. The suitable routes were

followed depending on the nature of the targeted products and the reaction yields were

moderate to excellent. / Thesis (M.Sc.)-University of KwaZulu-Natal, Pietermaritzburg,2010.

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:ukzn/oai:http://researchspace.ukzn.ac.za:10413/2612
Date January 2010
ContributorsSoares, A. M.
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
TypeThesis

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