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Predikce vazebních míst proteinu p53 / Prediction of p53 Protein Binding Sites

Protein p53 which is encoded by gene TP53 plays crucial role in cell cycle as a regulator of transcription of genes in cases when cell is under stress. Therefore p53 acts like tumor suppressor. Understanding the pathway of p53 regulation as well as predicting its binding sites on p53 regulated genes is one of the major concerns of modern research in genetics and bioinformatics. In first part of this project we aim to introduce basics from molecular biology to better understand the p53 protein pathway in gene transcription and introduction to analysis of prediction of p53 binding sites. Second part is about implementation and testing of tool which would be able to predict transcription factor binding sites for protein p53.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:234992
Date January 2015
CreatorsRadakovič, Jozef
ContributorsVogel, Ivan, Martínek, Tomáš
PublisherVysoké učení technické v Brně. Fakulta informačních technologií
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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