One of the major goals in large-scale genomic studies is to identify genes with a prognostic impact on time-to-event outcomes, providing insight into the disease's process. With the rapid developments in high-throughput genomic technologies in the past two decades, the scientific community is able to monitor the expression levels of thousands of genes and proteins resulting in enormous data sets where the number of genomic variables (covariates) is far greater than the number of subjects. It is also typical for such data sets to have a high proportion of censored observations. Methods based on univariate Cox regression are often used to select genes related to survival outcome. However, the Cox model assumes proportional hazards (PH), which is unlikely to hold for each gene. When applied to genes exhibiting some form of non-proportional hazards (NPH), these methods could lead to an under- or over-estimation of the effects. In this thesis, we develop methods that will directly address t / Statistics
| Identifer | oai:union.ndltd.org:TEMPLE/oai:scholarshare.temple.edu:20.500.12613/2446 |
| Date | January 2017 |
| Creators | Spirko, Lauren Nicole |
| Contributors | Tang, Cheng-Yong, Devarajan, Karthik, Chitturi, Pallavi, Dong, Yuexiao, Obradovic, Zoran |
| Publisher | Temple University. Libraries |
| Source Sets | Temple University |
| Language | English |
| Detected Language | English |
| Type | Thesis/Dissertation, Text |
| Format | 189 pages |
| Rights | IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available., http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | http://dx.doi.org/10.34944/dspace/2428, Theses and Dissertations |
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