Prediction and searching for homologous protein sequences is one of important tasks which are currently being addressed in the area of bioinformatics. According to the determination of homologous sequences of unknown protein sequence it is often possible to determine its structure and function in the organism. For searching homologous sequences, the most frequently used tools are based on direct sequence comparison, profile comparison or on the use of hidden Markov models. There is no universal method better than all others. To satisfy user`s request on needed sequence identity between domains and error rate between founded true positive and false positive pairs, the selection of proper method and its settings is needed. This work is focused to create tool which will help user to choose the best method and its settings according to his requirements. It was created on the basis of the analysis of method results with different settings. In addition, the implemented application offers the possibility to run this method and show its results.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:234987 |
| Date | January 2015 |
| Creators | Chlupová, Hana |
| Contributors | Bendl, Jaroslav, Martínek, Tomáš |
| Publisher | Vysoké učení technické v Brně. Fakulta informačních technologií |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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