Cyclodextrins are well known for their ability to encapsulate molecules and have
captured the attention of scientists for many years. This ability alone makes
cyclodextrins attractive for study, research, and applications in many fields including
food, cosmetics, textiles, and the pharmaceutical industry.
In this thesis, we specifically look at the ability of the three native cyclodextrins, alpha,
beta, and gamma cyclodextrin (α-CD, β-CD, and γ-CD, respectively), to encapsulate the
drug molecule, quinine, a small hydrophobic, lipophilic molecule used to treat malaria,
leg cramps, and other similar conditions. This encapsulation process is driven by the
molecular interactions, which have been studied by NMR techniques at different
temperatures (288 K, 293 K, 298 K, 303 K, 308 K) and pH values (7.4, 11.5). These factors
(temperature and pH) influence these molecular interactions, which in turn significantly
affects the entire encapsulation process. Detailed studies of the influences of
temperature and pH on the interactions that drive the encapsulation may suggest some
new directions into designing controlled drug release processes.
Results obtained throughout the course of this work indicate that β-CD is the best native
cyclodextrin to bind quinine, and that binding is best at pH = 11.5. It was found that
temperature does not significantly affect the binding affinity of quinine to either α-CD,
β-CD, or γ-CD.
| Identifer | oai:union.ndltd.org:kaust.edu.sa/oai:repository.kaust.edu.sa:10754/666039 |
| Date | 11 1900 |
| Creators | Poulson, Benjamin Gabriel |
| Contributors | Jaremko, Mariusz, Biological and Environmental Sciences and Engineering (BESE) Division, Arold, Stefan T., Saikaly, Pascal, Gao, Xin |
| Source Sets | King Abdullah University of Science and Technology |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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