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Experimentální studium a teoretické modelování transdermálního transportu aktivních látek z gelových matric / Experimental study and modelling of the transdermal penetration of active species from gels

This diploma thesis deals with design and experimental study of transdermal transport of pharmaceutically active agents from gel matrices, which contain humic substance in its structure. A model absorption membrane was represented by the skin of pig´s earlobes. The study of the release of active substances and Lignohumte was performed due to the vertical diffusion cells. The amount of released humic substance was characterized by UV-VIS method and the amount of released active agent from gel matrix was determined by HPLC-DAD. The most interesting finding of this diploma thesis was that Lignohumate enhances transdermal transport of active agents and supports their release from gel samples to the particular environment.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:240533
Date January 2016
CreatorsPalanová, Veronika
ContributorsOpatřilová, Radka, Sedláček, Petr
PublisherVysoké učení technické v Brně. Fakulta chemická
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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