Background: Hyperbaric Oxygen Therapy (HBOT) is used to promote soft and hard tissue repair at sites of injury or disease. It is not known whether it has any effect on uninjured tissues. Objective: To evaluate the effect of HBO on vertebral bones distant from a calvarial surgical site. Materials and Methods: 22 male New Zealand white rabbits were divided into two groups (n=11). All animals underwent surgery to produce bilateral calvarial critical sized defects. Group 1 received HBOT while Group 2 served as controls breathing room air (NBO). The Marx HBO protocol was used (90min, 100% oxygen at 2.4 ATA, 5 days a week for 4 weeks). Subjects were sacrificed at 6 weeks. The vertebrae were analyzed by micro-CT (μCT) and histology. Results: There were no statistical significant differences between the two groups. Conclusion: we concluded that there were no harmful effects of HBOT on non-injured vertebrae at 6 weeks.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/30161 |
| Date | 01 December 2011 |
| Creators | Alghamdi, Mohammed Y. M. |
| Contributors | Peel, Sean |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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