Abstract -1
The immune response occurred in the mice infected with
Angiostrongylus cantonensis was mainly humoral immune
response. This study was designed to compare the systemic and
localized humoral immune responses occurred after primary and
secondary infections in C57BL/6J mice. Eight weeks after the
primary infection with 20 third-stage larvae, each mouse received a
second inoculation of the same dosage. Specific serum IgM, IgG
and IgE were found in the second week after primary infection.
However, the titers of IgG1 and IgG2b increased at the fourth week
after primary infection. Antibodies of these mentioned increased
continuously as the progress of infection. On the other hand, the
IgM and IgG1 titers increased in brain tissue infusion since the forth
week after primary infection, while the titer of IgG start to elevate at
the sixth week. Nevertheless, the increase of IgG2B was only
noticed at the sixth week and no significant change was observed
for IgG2a and IgE. After the secondary infection, serum IgM titers
increased while the titer of IgG1 in the brain tissue infusion
decreased. Results of Western blot showed that IgG1and IgE in the
brain tissue infusion lost the ability to recognize a 42 kDa molecule
of the somatic and excreting-secreting antigens of fifth-stage
larvae. These variations could be used in the diagnosis of the early
stage of mice that re-infected with Angiostrongylus cantonensis. Abstract -2
The radiographic lateral views of the skulls of the mice infected
with Angiostrongylus cantonensis were taken. Thus, the
parietofrontal index ( PI ) was obtained by measuring and
calculating the distances among specific positions on their skulls.
Compared with the controls, a significant elevation over the top of
the crania of the cases was observed sixty days post-infection. In
addition, the phenomenon emerged apparently during the second
to the fourth week post-infection. These findings are able to be
applied as the external diagnostic references for the infection
course of mice infected with Angiostrongylus cantonensis.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0910102-072048 |
| Date | 10 September 2002 |
| Creators | Yang, Zhi-Ya |
| Contributors | David Chao, Jyh-Wei Shin, Gan-Nan Chang |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0910102-072048 |
| Rights | off_campus_withheld, Copyright information available at source archive |
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