Recent experiments are bringing to the fore more and more information about the
effects of different treatments on the gene expression of different genes. The results
obtained from these experiments show that some definite trends are observed in different
genes in the Human Embryonic Kidney and Human Colon Adenocarcinoma Grade II
cell lines. The difference in the gene expressions of the two cell lines motivates the
problem in this thesis. The thesis provided intervention methods to make the colon
cancer cell line genes behave more like their Human Embryonic Kidney cell line
counterparts. Two methods of intervention were introduced. The first method was the
simpler on-off control intervention while the second method used a more advanced
proportional integral control to meet the goal. A comparison of these two intervention
methods showed the clear implementational advantages of proportional integral control
over on-off control.
| Identifer | oai:union.ndltd.org:tamu.edu/oai:repository.tamu.edu:1969.1/ETD-TAMU-2009-05-572 |
| Date | 16 January 2010 |
| Creators | Mendonca, Rouella J. |
| Contributors | Datta, Aniruddha |
| Source Sets | Texas A and M University |
| Language | en_US |
| Detected Language | English |
| Type | Book, Thesis, Electronic Thesis |
| Format | application/pdf |
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