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Design and Synthesis of New Enediyne Containing Antitumor Agents

A total of 27 new enediyne analogs of combretastatin A-4 (CA-4), with different substituents (Cl, Br, OCH3, SCH3 or N(CH3)2 ) of the aryl A-ring, were designed, synthesized, and evaluated for their growth inhibition activity against human tumor cell lines. Among them, compound 14a showed most significant inhibition activity against Hep3B (0.22 £gM), A-549 (0.49 £gM) and MCF-7 (0.22 £gM), and these activities were greater than CA-4. The enediyne analog 14a may be consider as a new drug candidate worthy of further investigation and development as a potential antitumor agent.

Identiferoai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0708111-165920
Date08 July 2011
CreatorsChen, Pei-chi
ContributorsTzeng, Cherng-Chyi, Wu, Ming-Jung, Ong, Chi-Wi
PublisherNSYSU
Source SetsNSYSU Electronic Thesis and Dissertation Archive
LanguageCholon
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0708111-165920
Rightsnot_available, Copyright information available at source archive

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