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Previous issue date: 2011-05-31 / The Spotrhrix schenckii is widely dispersed in nature, especially in temperate and
tropical climates. Sporotrichosis is the most common human subcutaneousmycosis in Latin
America. In domestic feline, tissues can be found with a abundance of this parasite, fact that it
is not usual in other species, so becoming a significantzoonoticagent. The objective in this
study was to evaluate the regressiontimeoftheclinical disease, the side effects with Potassium
Iodide (KI) administration, in dosis of 10 and 20mg/kg of weight, also evaluation the total T4
hormone concentrations, as well as the possible alterations of hemogram, and renal and
hepatic serum biochemistrybyusingthismedication. Were used in this experimentation 14
domestic cats (Felis catusdomesticus), 11 males and three females, with indefinite race, and a
mean age of 3.7 years old and average weight of 3.9 kg, with the disease sporotrichosis, all
from Rio de Janeiro city. The animal selection was done through the confirmation of the
sporotrichosis disease, by collecting material and conducting to mycological culture
procedure. The animals were divided into two groups randomly: group I (10 mg of KI/ kg of
weight), and group II (20 mg of KI/ kg of weight). Clinical and laboratory evaluations were
performed in all cats in the study. Besides the total T4, the following laboratory tests were
performed: hemogram, urea, creatinine, alkaline phosphatase, alanine-aminotransferase,
gamma-glutamyltransferase, aspartate-aminotransferase. All tests were repeated every 15
days, and clinical evaluation was performed daily. This study concluded after comparison
between the two groups that weren?t significant alterations in time regression of disease, as
well as in that laboratorial analysis, but there were differences in side effects, so, dosis of 10
mg / kg of weight, once daily was the most right treatment of feline sporotrichosis / O Spotrhrix schenckii, agente etiol?gico da esporotricose,? amplamente disperso na
natureza, especialmente em ambientes de climas temperados e tropicais. A esporotricose ? a
micose subcut?nea humana mais comum na Am?rica Latina, e o felino tem potencial
zoon?tico significativo. O objetivo deste trabalho foi avaliar o tempo de regress?o da doen?a
cl?nica e as fun??es hep?tica, renal e tiroideana, com uso do iodeto de pot?ssio (IK) nas doses
de 10 ou 20 mg/kg de peso, para tratamento da micose. Foram utilizados 14 felinos
dom?sticos (Felis catus domesticus), sendo 11 machos e tr?s f?meas, ra?a indefinida, com
idade m?dia de 3,7 anos e peso m?dio 3,9 kg, portadores da doen?a e provenientes do
Munic?pio do Rio de Janeiro. A sele??o dos animais foi realizada atrav?s da confirma??o da
doen?a, por meio da coleta de material e realiza??o de cultura micol?gica. Os animais foram
divididos em dois grupos, de forma aleat?ria: grupo I (dose de 10 mg de IK/kg de peso) e
grupo II (dose de 20 mg de IK/kg de peso), com m?dia do tempo de tratamento de 63 dias.
Avalia??o cl?nica e laboratorial foi realizada em todos os gatos do estudo. Al?m do T4 total,
os seguintes exames laboratoriais foram realizados: hemograma, ur?ia, creatinina, fosfatase
alcalina, alanina-aminotransferase, gama-glutamiltransferase, aspartato-aminotransferase.
Todos os exames foram repetidos a cada 15 dias, do in?cio ao final dotratamento e avalia??o
cl?nica foi realizada diariamente. Este estudo concluiu, comparando-se os dois grupos, que
n?o houve diferen?a estatisticamente significativa no tempo de regress?o da doen?a, mas
houve diferen?as nos efeitos colaterais. Os animais do grupo I que apresentaram v?mitos e
diarr?ia foram em n?mero de dois e os animais do grupo II apresentaram efeits colaterais cmo
v?mitos, diarr?ia, prostra??o, anorexia, desidrata??o, febre, saliva??o, pelagem seca.Sendo a
dose de 10 mg/kg, uma vez ao dia, a mais adequada para o tratamento de esporotircose felina,
pois n?o provocou altera??es cl?nicas, laboratoriais e hormonais significativas
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1212 |
| Date | 31 May 2011 |
| Creators | Sena, Priscila das Merc?s de |
| Contributors | Scherer, Paulo Oldemar, Almeida, Elan Cardozo Paes, Botelho, Jonimar Pereira, Barone, Francisco, Ferreira, Terezinha |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas), UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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