Imidazo[1,5-a]pyridines are an important and versatile class of N-heterocyclic compounds due
to their stability, unique biological, and photochemical properties. Due to the conjugation and
charged structure, their properties are extended to conducting electricity and also have
electronic properties. They can be used for chelating transition metals especially heavy metals that can be harmful to living things (including human).
The aim of this research was to develop more useful imidazo[1,5-a]pyridines which are stable in both free and complexed state. A variety of imidazo[1,5-a]pyridyl compounds was synthesized following three useful methods namely (i) The first route includes the isolation of
imine intermediates which were then treated with phosphorus oxychloride in one case and
hydrochloric acid in another case as catalysts. Both cases resulted in the yield of the same imidazo[1,5-a]pyridyl compounds. (ii) The second route was the development on the first route for those imine intermediates that could not be isolated and only hydrochloric acid
catalyst was used. In both the first and second routes, paraformaldehyde was used for the ringclosure step of the reaction. The last route for the formation of imidazo[1,5-a]pyridyl
compounds did not involve the use of the paraformaldehyde reagent. The suitable routes were
followed depending on the nature of the targeted products and the reaction yields were
moderate to excellent. / Thesis (M.Sc.)-University of KwaZulu-Natal, Pietermaritzburg,2010.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:ukzn/oai:http://researchspace.ukzn.ac.za:10413/2612 |
| Date | January 2010 |
| Contributors | Soares, A. M. |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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