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Immunohistochemical characterization of neuronal cilia in the rat central nervous system.

An anti-G"11 antibody was used to label neuronal cilia throughout the rat central nervous system. Immunoreactive cilia were observed in every examined region of the rat CNS, but not in monkey or mouse tissue. Antibodies to G"q and G"q/11 failed to label cilia. Immunoreactive cilia were observed as early as postnatal day 0 in spinal tissue, and postnatal day 3 in hypothalamic tissue. There was a statistically significant negative correlation between a region's mean cilium length and that region's distance to the nearest ventricle; regions nearest ventricles were those with the longest cilia. This correlation suggests neuronal cilia may function as chemosensors, detecting substances as they move out from the cerebrospinal fluid and into the extracellular space of the brain.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc3136
Date05 1900
CreatorsHughes, Rhome
ContributorsSchwark, Harris, Fuchs, Jannon L., Gross, Guenter W.
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
FormatText
RightsPublic, Copyright, Hughes, Rhome, Copyright is held by the author, unless otherwise noted. All rights reserved.

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