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Histologická analýza terapie melanomu B16-F10 pomocí agonistů TLRs a fagocytárních receptorů / Histologic analysis of melanoma B16-F10 therapy by agonist of TLRs and fagocyte receptors

The aim of submited Thesis was to contribute to illustration on effect of TLR and fagocytate receptors in melanoma B16-F10 treatment with mouse model. Currently, a consequence of different ligands of fagocyte receptors and their combination with liposacharide (LPS) was tested. Ligands of fagocytate receptors was used in form enabled inside tumor cells anchoring. It deals with these compounds: f-MLFKK-BAM4000, laminarin-BAM4000, mannan-BAM4000. Gained results confirmed that previously observed huge synergy of LPS (activation of TLR4) and activation of phagocytic receptors by ligands anchored to tumor cells found the clarification in the form of extensive necrotization of tumor mass at the histological level.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:172978
Date January 2014
CreatorsDIVOKÁ, Petra
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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