Analysis of non-coding RNA expression in medium spiny neurons of Huntington disease model mice / ハンチントン病モデルマウスの中型有棘神経細胞におけるノンコーディングRNAの発現変化 / ハンチントンビョウ モデル マウス ノ チュウガタ ユウキョク シンケイ サイボウ ニオケル ノンコーディング RNA ノ ハツゲン ヘンカ

Description

Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects the transcriptional profile of neurons by disrupting the activities of transcriptional machinery and alters expression of many genes. In this study, we identified dysregulated non-coding RNAs (ncRNAs) in medium spiny neurons of 4-week-old HD model mouse. Also, we observed the intracellular localizations of Abhd11os and Neat1 ncRNAs by ViewRNA in situ hybridization, which could provide more precise detection, suggesting that it is a useful method to investigate the expression changes of genes with low expression levels. / 博士(理学) / Doctor of Philosophy in Science / 同志社大学 / Doshisha University

Links & Downloads

1. https://doshisha.repo.nii.ac.jp/?action=repository_uri&item_id=1550
2. http://id.nii.ac.jp/1707/00001542/
3. 脳科学研究科
4. Graduate School of Brain Science
5. BB29390837
6. https://doshisha.repo.nii.ac.jp/?action=repository_action_common_download&item_id=1550&item_no=1&attribute_id=21&file_no=1
7. https://doshisha.repo.nii.ac.jp/?action=repository_action_common_download&item_id=1550&item_no=1&attribute_id=21&file_no=2
8. 34310甲第1031号

Tags

Gene expression

Non-coding RNA

Huntington disease

Abhd11os

Neat1

ViewRNA in situ hybridization

Microarray

Additional Fields

Identifer	oai:union.ndltd.org:doshisha.ac.jp/oai:doshisha.repo.nii.ac.jp:00001550
Date	22 March 2019
Creators	朴 洪宣, Hongsun Park
Source Sets	Doshisha University
Language	English
Detected Language	English
Type	Thesis or Dissertation
Format	application/pdf
Source	https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13106336/?lang=0