Inflammation has been shown to play an integral role in a number of different disease processes. There is evidence that measurements of the systemic immune/inflammatory response are associated with mortality in patients with certain malignancies, as well as those with atherosclerotic disease. A variety of readily available inflammation-based prognostic scores, combining serum constituents of the systemic immune/inflammatory response, have been suggested for use in these patient groups. However, it is unclear whether systemic inflammation-based scores are universally associated with mortality across all tumour types and whether this relationship persists in atherosclerotic conditions including cardiovascular and cerebrovascular disease. The optimal constituents of such a score are also still to be determined. The present thesis further examines these topics with specific reference to: 1. The relationship between the presence of cancer, an inflammation-based prognostic score and biochemical parameters in a large group of unselected patients. 2. The relationship between an inflammation-based prognostic score and cancer survival in patients with malignancies at a number of different sites. 3. A comparison of commonly available inflammation-based prognostic scores in patients with cancer. 4. The prognostic value of a derived neutrophil to lymphocyte ratio, commonly available in patients with cancer undergoing chemotherapy. 5. The optimal serum constituents of the systemic inflammation-based Glasgow Prognostic Score (optimised) in patients with cancer. 6. The optimal constituents and prognostic value of a systemic inflammation-based score for predicting cardiovascular, cerebrovascular and all-cause mortality.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:631072 |
| Date | January 2014 |
| Creators | Proctor, Michael J. |
| Publisher | University of Glasgow |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://theses.gla.ac.uk/5780/ |
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