The synthesis of 3,5-disubstituted indolizidines

Description

A dissertation submitted to the Faculty of Science, University of the
Witwatersrand, Johannesburg, in fulfilment of the requirements for the
degree of Master of Science. January 1996. / Aspects of the literature of the ant venom alkaloid monomorine I and its stereoisomers
were reviewed.
Racemic 5-butyl-2-pyrrolidinone was synthesised in two steps from methyl acrylate and
1-nitropentane, A thionation step yielded 5-butylpyrrolidine-2-thione. The Michael
addition reaction between 5-butylpyrrolidine-2-thione and ethyl crotonate proceeded with
difficulty to form a separable mixture of diastereomers of 5-butyl-l-(2-ethoxycarbonyl-l-methylethyl)
pyrrolidine-2-thione. [Abbreviated Abstract. Open document to view full version] / AC2017

Links & Downloads

1. Cheesman, Penelope, Sue (1996) The synthesis of 3,5-disubstituted indolizidines, University of the Witwatersrand, Johannesburg, <http://hdl.handle.net/10539/22411>
2. http://hdl.handle.net/10539/22411

Tags

Indole alkaloids--Synthesis

Organic compounds--Synthesis

Additional Fields

Identifer	oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/22411
Date	January 1996
Creators	Cheesman, Penelope, Sue
Source Sets	South African National ETD Portal
Language	English
Detected Language	English
Type	Thesis
Format	Online resource (151 leaves), application/pdf