In the thesis, a statistical simulation-based framework is presented that is intended for making sample size and power considerations prior to case-control association studies. It reviews biological background and biallelic single- and multiple-SNP disease models, with a focus on single-SNP models. Odds ratios, multiple testing, sample size, statistical power and the genomeSIM package are also reviewed. The framework is tested with the MAX stat method on a dominant disease model, demonstrating that it can be used for assessing whether different sample sizes are sufficient for detecting a causal SNP.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:ntnu-9763 |
| Date | January 2008 |
| Creators | Edsberg, Erik |
| Publisher | Norges teknisk-naturvitenskapelige universitet, Institutt for matematiske fag, Institutt for matematiske fag |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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