The development of microlectronic lab-on-a-chip devices (LOACs) can now be
pursued thanks to the continous advances in silicon technology. LOACs are miniaturized devices
whose aim is to perform in a more efficient way specific chemical or biological analysis protocols
which are usually carried out with traditional laboratory equipment. In this application area, CMOS
technology has the potential to integrate LOAC functionalities for cell biology applications in single
chips, e.g. sensors, actuators, signal conditioning and processing circuits. In this work, after a
review of the state of the art, the development of a CMOS prototype chip for individual cell
manipulation and detection based on dielectrophoresis will be presented. Issues related to the
embedded optical and capacitive detection of cells will be discussed together with the main
experimental results obtained in manipulation and detection of living cells and microparticles.
| Identifer | oai:union.ndltd.org:unibo.it/oai:amsdottorato.cib.unibo.it:15 |
| Date | 22 April 2005 |
| Creators | Romani, Aldo <1975> |
| Contributors | Guerrieri, Roberto |
| Publisher | Alma Mater Studiorum - Università di Bologna |
| Source Sets | Università di Bologna |
| Language | English |
| Detected Language | English |
| Type | Doctoral Thesis, PeerReviewed |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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