Mast cells reside at tissue sites closely interfacing the environment and play a role in host
defense against pathogens. Mast cell responses to respiratory syncytial virus (RSV), a
major cause of severe respiratory tract infections and subsequent bronchiolitis, are not
fully elucidated. Human cord blood-derived mast cells (CBMCs) and the HMC-1 mast
cell line supported low levels of RSV antigen expression as compared with airway
epithelial cells. RSV inoculated mast cells up-regulated the expression of several
chemokines such as CCL4, CCL5 and CXCL10, as well as type I and III interferons.
Type I interferon receptor blockade on RSV-inoculated HMC-1 cells had no effect on
chemokine production or viral antigen expression. These data show that mast cells
respond to RSV by expressing various cytokines and chemokines that may enhance
inflammation and effector cell recruitment during RSV disease.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:NSHD.ca#10222/15709 |
| Date | 08 July 2011 |
| Creators | Al-Afif, Ayham |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
Page generated in 0.0017 seconds