Research on biosynthesis of tobacco mosaic virus (TMV) ribonucleic acid (RNA) in vitro has been reported by Cochran, et al; Karasek and Schramm; Kim and Wildman; Cornuet and Astier; and Tongur and Baland in. It has been postulated that the replication of a number of viruses containing single-stranded RNA is accompanied by the formation of a virus-specific double-stranded helical RNA, the replicative form. This has been demonstrated both for animal and bacterial viruses including MS2. The double helical structure of purified replicative form of MS2 was established by X-ray diffraction studies. One of the strands was shown to be a viral RNA strand of the parental type ("plus" strand), the other being complementary to it ("minus" strand). Studies on Escherichia coli infected with RNA phages suggest that a structure containing both a "plus 11 and a "minus " strand is an obligatory intermediate in viral reproduction.
| Identifer | oai:union.ndltd.org:UTAHS/oai:digitalcommons.usu.edu:etd-4842 |
| Date | 01 May 1966 |
| Creators | Fok, Agnes P. |
| Publisher | DigitalCommons@USU |
| Source Sets | Utah State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | All Graduate Theses and Dissertations |
| Rights | Copyright for this work is held by the author. Transmission or reproduction of materials protected by copyright beyond that allowed by fair use requires the written permission of the copyright owners. Works not in the public domain cannot be commercially exploited without permission of the copyright owner. Responsibility for any use rests exclusively with the user. For more information contact digitalcommons@usu.edu. |
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