An approach for optimizing medical treatment as a function of measurable patient data is analyzed using a two-network system. The two-network approach is inspired by the field of control systems: one network, called a patient model (PM), is used to predict the outcome of the treatment, while the other, called a treatment network (TN), is used to optimize the predicted outcome. The system is tested with a variety of functions: one objective criterion (with and without interaction between treatments) and multi-objective criteria (with and without interaction between treatments). Data are generated using a simple Gaussian function for some studies and with functions derived from the medical literature for other studies. The experimental results can be summarized as follows: 1) the relative importance of symptoms can be adjusted by applying different coefficient weights in the PM objective functions. Different coefficients are employed to modulate the tradeoffs in symptoms. Higher coefficients in the cost function result in higher accuracy. 2) Different coefficients are applied to the objective functions of the TN when both objective functions are quadratic, the experimental results suggest that the higher the coefficient the better the symptom. 3) The simulation results of training the TN with a quadratic cost function and a quartic cost function indicate the threshold-like behavior in the quartic cost function when the dose is in the neighborhood of the threshold. 4) In general, the network illustrates a better performance than the quadratic model. However, the network encounters a local minima problem. Ultimately, the results indicate a proof of idea that this framework might be a useful tool for augmenting a clinicians decision in selecting dose strengths for an individual patient need.
| Identifer | oai:union.ndltd.org:PITT/oai:PITTETD:etd-09242003-142535 |
| Date | 17 February 2011 |
| Creators | Sanguansintukul, Siripun |
| Contributors | Brusilovsky, Peter, Parmanto, Bambang, Iyengar, Satish, Druzdzel, Marek, Munro, Paul |
| Publisher | University of Pittsburgh |
| Source Sets | University of Pittsburgh |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.pitt.edu/ETD/available/etd-09242003-142535/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Pittsburgh or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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