Breast cancer is the most crucial cancer type among all other cancer types. There are many imaging techniques used to screen breast carcinoma. These are mammography, ultrasound, computed tomography, magnetic resonance imaging, infrared imaging, positron emission tomography and electrical impedance tomography. However, there is no gold standard in breast carcinoma diagnosis. The object of this study is to create a hybrid system that uses thermal and electrical imaging methods together for breast cancer diagnosis. Body tissues have different electrical conductivity values depending on their state of health and types. Consequently, one can get information about the anatomy of the human body and tissue&rsquo / s health by imaging tissue conductivity distribution. Due to metabolic heat generation values and thermal characteristics that differ from tissue to tissue, thermal imaging has started to play an important role in medical diagnosis. To increase the temperature contrast in thermal images, the characteristics of the two imaging modalities can be combined. This is achieved by implementing thermal imaging applying electrical currents from the body surface within safety limits (i.e., thermal imaging in active mode). Electrical conductivity of tissues changes with frequency, so it is possible to obtain more than one thermal image for the same body. Combining these images, more detailed information about the tumor tissue can be acquired. This may increase the accuracy in diagnosis while tumor can be detected at deeper locations. Feasibility of the proposed technique is investigated with analytical and numerical simulations and experimental studies. 2-D and 3-D numerical models of the female breast are developed and feasibility work is implemented in the frequency range of 10 kHz and 800 MHz. Temporal and spatial temperature distributions are obtained at desired depths. Thermal body-phantoms are developed to simulate the healthy breast and tumor tissues in experimental studies. Thermograms of these phantoms are obtained using two different infrared cameras (microbolometer uncooled and cooled Quantum Well Infrared Photodetectors). Single and dual tumor tissues are determined using the ratio of uniform (healthy) and inhomogeneous (tumor) images. Single tumor (1 cm away from boundary) causes 55 ° / mC temperature increase and dual tumor (2 cm away from boundary) leads to 50 ° / mC temperature contrast. With multi-frequency current application (in the range of 10 kHz-800 MHz), the temperature contrast generated by 3.4 mm3 tumor at 9 mm depth can be detected with the state-of-the-art thermal imagers.
| Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/12614168/index.pdf |
| Date | 01 February 2012 |
| Creators | Carlak, Hamza Feza |
| Contributors | Gencer, Nevzat G |
| Publisher | METU |
| Source Sets | Middle East Technical Univ. |
| Language | English |
| Detected Language | English |
| Type | Ph.D. Thesis |
| Format | text/pdf |
| Rights | Access forbidden for 1 year |
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