M.Tech. (Homeopathy) / Insulin resistance (IR) is a metabolic derangement and a documented clinical feature of the metabolic syndrome. It is an important risk factor in the development of cardiovascular disease and Type 2 Diabetes mellitus. Insulin resistance is often characterized by an increased Homeostasis Model Assessment (HOMA) index and hyperinsulinaemia, but it may also be present without increased insulin levels. Metabolic syndrome is a cluster of risk factors characterized by visceral adiposity (a girth exceeding 102cm in men and 88cm in women), dyslipidaemia (low HDL and raised triglycerides levels), hypertension and dysglycaemia, particularly raised fasting blood glucose levels, predisposing individuals to cardiovascular disease and Type 2 Diabetes mellitus. Diaglukon™ Dr Reckeweg R40 is formulated as an adjunct in the treatment of type 2 diabetes mellitus to assist in lowering the blood glucose (hyperglycaemia). The aim of the research was to evaluate and document its efficacy in the treatment of insulin resistance. A cohort of forty five participants between the ages of nineteen to forty five years was randomized into a double blind placebo controlled, 16 week, clinical study. Participants were matched according to age, race and gender. Anthropometric evaluation consisted of weight, height, BMI, waist circumference and blood pressure readings; these were recorded at 4 weekly intervals for sixteen weeks. Metabolic data included fasting insulin, glucose and a full lipogram at baseline (Week 0) and at study conclusion (Week 16). The insulin and glucose was used to calculate the HOMA index as a measure of insulin resistance (IR). Non parametric statistical analysis was conducted on all parameters using the SPSS statistical programme...
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uj/uj:7958 |
| Date | 27 January 2014 |
| Source Sets | South African National ETD Portal |
| Detected Language | English |
| Type | Thesis |
| Rights | University of Johannesburg |
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