Although insulin resistance of glucose and fat metabolism in type 2 diabetes mellitus (T2DM) is firmly established, that of protein remains controversial for methodological reasons. A hyperinsulinemic (40MU/m2·min) euglycemic (5.5 mmol/L) isoaminoacidemic (postabsorptive concentrations) clamp was combined with [3-3H]glucose and [1-13C]leucine kinetics to concurrently assess protein and glucose metabolism in 10 hyperglycemic men with T2DM and 11 men without (all BMI=29+/-kg/m2), matched also for age, body composition, and waist circumference. In response to hyperinsulinemia, protein turnover and synthesis were stimulated in controls, but not in T2DM. Both insulin-stimulated total and non-oxidative glucose disposal were diminished in T2DM vs. controls. There was a robust positive correlation between the change in synthesis and glucose disposal. Hence, there is an additive effect of T2DM, beyond that of having excess fat, on insulin resistance of whole body protein turnover and synthesis. Furthermore, protein sensitivity to insulin parallels that of glucose, establishing this as an important concern in T2DM management.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.101161 |
| Date | January 2006 |
| Creators | Pereira, Sandra M. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (School of Dietetics and Human Nutrition.) |
| Rights | © Sandra M. Pereira, 2006 |
| Relation | alephsysno: 002603182, proquestno: AAIMR32770, Theses scanned by UMI/ProQuest. |
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