Calcium/calmodulin-dependent protein kinase II (CaM kinase II) is demonstrated to exist in the ß-cell and immunopecipitation. Glucose and potassium significantly stimulate the rapid autophosphorylation of CaM kinase II and proportionally induce autonomous activity of the kinase in a dose-dependent manner that parallels insulin secretion. The activation of CaM kinase II, alloxan, KN-62 and KN-93, suggest that the enzyme is an integral component of insulin secretion and/or related processes in the β-cell.
Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc798159 |
Date | 12 1900 |
Creators | Wenham, Robert M. (Robert Michael) |
Publisher | North Texas State University |
Source Sets | University of North Texas |
Language | English |
Detected Language | English |
Type | Thesis or Dissertation |
Format | Text |
Rights | Public, Copyright, Copyright is held by the author, unless otherwise noted. All rights |
Page generated in 0.0014 seconds