Background: Delirium is common in critically ill trauma patients, yet there is no evidence-based standard of care sedation agent for this population.
Objective: This thesis aims to expand knowledge around dexmedetomidine, a sedative that has demonstrated potential superiority in other clinical patient populations.
Methods: We conducted a systematic review and network meta-analysis to compare the effectiveness of sedatives on delirium and associated patient outcomes. We conducted a health records review of sedated trauma patients at The Ottawa Hospital. We derived a simple mathematical model to demonstrate potential impact of dexmedetomidine on resources.
Results: There was no statistical difference between sedatives in preventing delirium. Approximately 79% of critical trauma patients were sedated with propofol, 18% with propofol and dexmedetomidine, and 3 with dexmedetomidine. Increasing the proportion of patients receiving propofol with adjunct dexmedetomidine could improve the number of freed ICU bed-days.
Conclusion: Dexmedetomidine could have potential benefits in improving outcomes for critically ill trauma patients.
| Identifer | oai:union.ndltd.org:uottawa.ca/oai:ruor.uottawa.ca:10393/44970 |
| Date | 18 May 2023 |
| Creators | Zitikyte, Gabriele |
| Contributors | Vaillancourt, Christian, Wells, George |
| Publisher | Université d'Ottawa / University of Ottawa |
| Source Sets | Université d’Ottawa |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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