No / The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding.
Graphical abstract
A designed analogue of the left half of azinomycin has been synthesized and unwinds supercoiled DNA.
Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/3908 |
Date | January 2005 |
Creators | Casely-Hayford, M.A., Pors, Klaus, Patterson, Laurence H., Gerner, C., Neidle, S., Searcey, M. |
Source Sets | Bradford Scholars |
Language | English |
Detected Language | English |
Type | Article, No full-text in the repository |
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