In-vivo investigations of renal tubular transport of the imino acids and glycine in man and rat have revealed that these compounds may share a common membrane transfer mechanism. However, the locus of "commonness” cannot be resolved by such techniques. In-vitro studies reported in this communication permit the application of Michaelis-Menten formulation to the kinetics of transport of these compounds in rat kidney cortex slices. The data indicate that L-proline, hydroxy-L-proline and glycine cannot be transported by identical mechanisms but that there is some aspect of these systems which is common. The order of affinity for transport in-vitro is proline > hydroxyproline > glycine, confirming in-vivo observations. The relation of these findings to the control of imino acid and glycine transport under certain genetic and maturational conditions in man, is discussed. A proposal as to the locus of commonness in transport generally, and more specifically in the transport of glycine and the imino acids, is discussed.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115319 |
| Date | January 1963 |
| Creators | Wilson, Onslow. H. |
| Contributors | Scriver, C. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Health Sciences.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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