>Magister Scientiae - MSc / This thesis reports on the syntheses of complexes of (arene) ruthenium (II) isoniazid Schiff base
ligands for antimicrobial studies. Isoniazid Schiff base ligands; isonicotinyl acid (2-hydroxy-5-
methyl-benzilidene)-hydrazide (L1), isonicotinyl acid (2-hydroxy-5-methoxy-benzilidene)-
hydrazide (L2), isonicotinyl acid (-5-chloro-2-hydroxy-benzilidene)-hydrazide (L3), isonicotinyl
acid (-5-bromo-2-hydroxy-benzilidene)-hydrazide (L4), isonicotinyl acid (2-hydroxy-5-nitrobenzilidene)-
hydrazide (L5) were prepared by condensation reaction under reflux from
equimolar amounts of isioniazid, which is an amine, with five different aldehyde moieties.
Ruthenium (II) complexes of these isoniazid Schiff base ligands (C1 - C5) were prepared in an
ethanolic solution under reflux and inert atmosphere at 60°C using Schlenk techniques.
Fourier transform infrared spectroscopy (FTIR), ultraviolet – visible spectroscopy,
thermogravimetric analysis, nuclear magnetic resonance and elemental analysis were the
characterization techniques that confirmed the successful preparation of the ligands. All the
ligands spectra displayed the imine functional group peak which confirmed the successful
preparation.
The ligands L1 – L5 and the complexes C1 – C5 were subjected to similar characterization
techniques which further confirmed the successful syntheses and the coordination of metal and
ligand by displaying a shift in their respective imine peaks and transitions values.
All the synthesized compounds were subjected to a standard antimicrobial test using three
microorganisms, Staphylococcus aureus, Methicillin resistant Staphylococcus aureus and
Pseudomonas aeruginosa. Out the ten compounds tested, only ligand L5 gave the best results
against Staphylococcus aureus.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/6574 |
| Date | January 2018 |
| Creators | Diyoka, Nkongolo Jean Blaise |
| Contributors | Onani, Martin O. |
| Publisher | University of the Western Cape |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Rights | University of the Western Cape |
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