Return to search

Application of Speciated Isotopes Dilution Mass Spectronmetry to the Assessment of Human Health and Toxic Exposure

Previous work by our research group demonstrated that quantitative chemical analysis of analytes, such as mercury and chromium species, in environmental matrices could be successfully carried out without using calibration curves and with correction for species interconversion by using EPA Method 6800A. This method encompasses isotope dilution mass spectrometry (IDMS) and speciated isotope dilution mass spectrometry (SIDMS), both of which are described in detail in chapter 1. Research described in this dissertation expands upon our earlier work by applying the method to the speciation of mercury in biological matrices, the speciation of glutathione in red blood cells and whole blood, and the analysis of enzyme activity in mammalian tissue. / Bayer School of Natural and Environmental Sciences; / Chemistry and Biochemistry; / PhD; / Dissertation;

Identiferoai:union.ndltd.org:DUQUESNE/oai:digital.library.duq.edu:etd/162261
Date19 February 2012
CreatorsFahrenholz, Timothy
ContributorsH. M. Skip Kingston, Lynne Divis, Rita Mihailescu, Stephanie Wetzel
Source SetsDuquesne University
Detected LanguageEnglish
RightsWorldwide Access;

Page generated in 0.0017 seconds