A novel non-invasive imaging method of unique k-space trajectory named “3D center-out EPI with cylindrical encoding” was developed and implemented for fast imaging of the human brain. The method based on a variant of 3D hybrid EPI combines advantages of the Cartesian and the radial encoding to achieve ultra-short echo time independent of spatial
resolution and reasonably short echo train length yielding a quality image of high signal-to-noise ratio. Unlike rectilinear sampling, the method offers not only less motion and flow artifacts but enables also the undersampling capability. As a result, the method improves temporal resolution by shortening the measurement time. Nonetheless, artifacts induced from
long-term drifts of the magnetic field as well as geometrical distortions caused by B0 inhomogeneity were removed with the average phase of the k-space center lines and an additional field map scan. Compared to other cylindrical k-space trajectories based on echo-planar imaging, which lead to progressively increasing echo time upon increasing the spatial resolution, the proposed method offers more benefits. As a significant application, imaging readout of the novel technique was applied to true 3D cine imaging which was later used in the combination of pseudo-continuous arterial spin labeling module in order to track a short arterial spin labeling (ASL) bolus of well-defined length along the fast passage through the large vessel compartment of the brain. Parametric maps of ASL signal change, estimated time-to-peak and ASL bolus width were extracted in order to characterize the macrovascular compartments of the brain-feeding arteries. Consequently, bolus dispersion within a single arterial branch was also assessed.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-211022 |
| Date | 26 September 2016 |
| Creators | Shrestha, Manoj |
| Contributors | Universität Leipzig,, Prof. Dr. rer. nat. Daniel Huster, Prof. Dr. rer. nat. Harald E. Möller, Prof. Dr. rer. nat. Jürgen Haase, Dr. rer. nat. habil. André Pampel |
| Publisher | Universitätsbibliothek Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:doctoralThesis |
| Format | application/pdf |
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