Non-ionic deep eutectic solvent (ni-DES) possesses various advantages such as good solvation, biodegradability, and non-toxicity which makes it a perfect and environmentally friendly solvent for organic synthesis. A Pd (OAc)2 catalyzed, Suzuki reaction of aryl bromide and N-heteroaryl halide with arylboronic acid in green and novel solvent (ni-DES) is described. In this work, the possibility of using ni-DES and the impact of this solvent on the scope of the reaction is studied. It is illustrated that using the mixture of N-alkyl derivatives of urea and acetamide as a green solvent for Suzuki reaction is achievable even though the desired amount of product was not obtained. However, the high yield in ni-DES can be obtained by choosing 4-bromobenzotrifluoride or 4-bromoanisole as the aryl bromide with arylboronic acid that possess the electron donating groups. Despite that, for getting more yield through Suzuki reaction in ni-DES more studies on optimization are required.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:lnu-106739 |
| Date | January 2021 |
| Creators | Hassanzadeh, Nazanin |
| Publisher | Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB) |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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