Introduction: The role that inflammation plays in the atherosclerotic disease process is well established. Obesity is coupled with a state of chronic inflammation and is associated with increased circulating inflammatory markers including C-Reactive Protein. Purpose: The purpose of this study was to evaluate the additive effect of aerobic or resistance exercise training to caloric restriction for weight loss on high sensitivity C-Reactive Protein changes compared to dietary restriction alone in class II and class III obese individuals. Methods: 24 healthy, sedentary, obese women underwent a 12-week diet and exercise intervention: Caloric restriction weight loss program with no exercise (DIET); Caloric restriction with aerobic endurance training (DIET+AT); and Caloric restriction with resistance training (DIET+RT). Blood was drawn at baseline and 12-weeks and assayed for hs-CRP. Results: Weight was decreased significantly in all groups in the intervention. Hs-CRP was unchanged at 12-weeks.Conclusions: In conclusion, this investigation was successful in producing weight loss, BMI decreases, decreases in body fat percentage, and positive changes in fitness markers, though no changes in hs-CRP were associated with weight loss or weight loss with exercise. Further investigations into the influence of weight loss and exercise on CRP levels among Class II and Class III individuals should be completed to examine and expand upon the results observed in this study.
| Identifer | oai:union.ndltd.org:PITT/oai:PITTETD:etd-08072011-144405 |
| Date | 25 August 2011 |
| Creators | Justice, Blake D. |
| Contributors | Rhob Evans, Erik Schelbert, Bethany Barone, Bret Goodpaster, John M. Jakicic |
| Publisher | University of Pittsburgh |
| Source Sets | University of Pittsburgh |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.pitt.edu/ETD/available/etd-08072011-144405/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Pittsburgh or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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