Layer-by-layer (LBL) polyelectrolyte capsules can be modified to incorporate stimuli such as superparamagnetic nanoparticles which respond to a magnetic field only when it is turned on. Thus, they can act as a switch to load or unload their drug cargo on demand. Specifically, magnetite is incorporated into bilayer capsules made of alternating poly(allylamine hydrochloride) (PAH) and poly(sodium-p-styrenesulfonate) (PSS) which surrounds calcium carbonate core. The core is then dissolved using ethylenediaminetetraacetic acid (EDTA). These capsules are loaded with at FITC-BSA conjugate and examined with fluorescence to show the unloading of the FITC-BSA from capsules as it brightens the entire field of view of the microscope. The results suggest that we can next load and unload an anticancer drug such as doxorubicin using the combination of microcapsule and alternating magnetic field (AMF) to treat the cancer cells. Preliminary data interprets that the low frequency AMF we use has little to no adverse effect cells viability. This coincides with the general thought that low frequency AMF signals are not harmful to humans. Therefore, as an alternative to hyperthermia methods which use heat, it may be possible to deliver the anticancer drugs specifically to the cells when and where it is needed.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc2257747 |
| Date | 12 1900 |
| Creators | Powell, Robert Darrel |
| Contributors | Habibi, Neda, Won, Youngwook, Yang, Yong |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | Text |
| Rights | Public, Powell, Robert Darrel, Copyright, Copyright is held by the author, unless otherwise noted. All rights Reserved. |
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