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The action of selenite on ATP synthesis in rat lens

A subcutaneous injection of sodium selenite (30 umol/kg body weight) in 10รข day old rats produced a cataract within 72 hours. Lens opacification was preceded by a 15% decrease in ATP content. Lens ATP did not fully recover to control concentrations by 11 days post-injection. A moderate correlation existed between lens weight and total ATP content in control lenses <r=O.509, n=153), but this relationship disappeared with selenite treatment <r=0.023, n=153). There was a significant inhibition by selenite on lens growth from 4 through 11 days after an injection. / Master of Science

Identiferoai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/45655
Date14 November 2012
CreatorsAdamchak, Marsha Ann
ContributorsBiochemistry and Nutrition, Hess, John L., Bunce, George Edwin, Gregory, Eugene M.
PublisherVirginia Tech
Source SetsVirginia Tech Theses and Dissertation
LanguageEnglish
Detected LanguageEnglish
TypeThesis, Text
Formatvii, 84 leaves, BTD, application/pdf, application/pdf
RightsIn Copyright, http://rightsstatements.org/vocab/InC/1.0/
RelationOCLC# 15183254, LD5655.V855_1986.A342.pdf

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