A short-term selection experiment was conducted with ICR albino mice produced by the reciprocal crossing of two lines of unselected animals which had been random-bred for 28 generations. Lines were developed by selecting for maximum and minimum serum cholesterol (SC) (lines CH and CL), voluntary physical activity (lines AH and AL), 56-day body weight (lines WH and WL) and feed intake (lines IH and IL). An unselected, random-bred control line was maintained with each pair of divergent selected lines (CC, AC, NC and IC, respectively). In the lines selected for SC, physical activity and 56-day body weight, selection was based on individual performance. Twenty-five paired matings plus five extra paired matings were used to perpetuate the lines each generation for five generations. The feed intake lines were perpetuated by within-sex, full-sib family selection with 30 paired matings per generation for five generations. / Ph. D.
| Identifer | oai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/40368 |
| Date | 29 November 2012 |
| Creators | Dunnington, E. Ann |
| Contributors | Genetics, White, John M., Vinson, William E., Siegel, Paul B., Hinkelmann, Klaus H., Thye, Forrest W. |
| Publisher | Virginia Tech |
| Source Sets | Virginia Tech Theses and Dissertation |
| Language | English |
| Detected Language | English |
| Type | Dissertation, Text |
| Format | x, 145 leaves, BTD, application/pdf, application/pdf |
| Rights | In Copyright, http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | OCLC# 22431505, LD5655.V856_1978.D85.pdf |
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