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Previous issue date: 2015-07-29 / Aging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. From 421 healthy community-dwelling older adults recruited, 61 subjects were identified with inverted CD4:CD8 T-cell ratio. Older individuals with a CD4:CD8 ratio < 1 had increased levels of plasma advanced oxidation protein products (AOPP) and Ferric Reducing Ability of Plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 T-cell ratio. The CMV IgG serology was negatively correlated with CD4:CD8 ratio. These markers were more evident among elderly men than women. Our data suggest a close relationship between chronic CMV infection and oxidative profile in older individuals in the midst of its influence on the peripheral T-cell subsets. / O envelhecimento tem sido associado com o aumento da gera??o de radicais livres, bem como com a imunossenesc?ncia. Estudos anteriores j? haviam identificado os idosos que apresentavam a invers?o da raz?o CD4:CD8 e a sorologia mais acentuada para citomegalov?rus (CMV). Aqui, investigamos marcadores de estresse oxidativo e as defesas antioxidantes em idosos com a rela??o invertida entre as c?lulas T CD4 e CD8. De um total de 421 idosos recrutados na comunidade, 61 sujeitos foram identificados com a invers?o da raz?o CD4:CD8. Os idosos com CD4:CD8<1 tinham n?veis aumentados de produtos proteicos de oxida??o avan?ada (AOPP) e atividade antioxidante total pelo m?todo de redu??o do ferro (FRAP) no plasma, mas n?veis reduzidos de subst?ncias reativas ao ?cido tiobarbit?rico (TBARS), em compara??o com indiv?duos com raz?o CD4:CD8 normais. A sorologia para CMV (IgG) foi negativamente correlacionada com a raz?o CD4:CD8. Estes marcadores foram mais evidentes entre os homens do que as mulheres idosas. Nossos dados sugerem uma estreita rela??o entre a infec??o por CMV cr?nica e perfil oxidativo em indiv?duos mais velhos no meio de sua influ?ncia sobre os subtipos de c?lulas T perif?ricas.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/6383 |
| Date | 29 July 2015 |
| Creators | M?ller, Guilherme Cerutti |
| Contributors | Bauer, Mois?s Evandro |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Biologia Celular e Molecular, PUCRS, Brasil, Faculdade de Bioci?ncias |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 8198246930096637360, 600, 600, 600, 36528317262667714, -3439178843068202161 |
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