Investigation on the chemical constituents of the Formosan soft coral Sinularia gibberosa, collected by hand using scuba off the coast of Kenting, had led to the isolation of seven new cembranoids , gibberorenes A-G¡]2-8¡^, three new sterols, gibberoketosterol B¡]10¡^, gibberoepoxysterol¡]11¡^, gibberoketosterol C ¡]12¡^ along with two known compounds, (1Z,3E,7E,11S,12S,14S)-11,12-epoxycembra-1,3,7
-trien-14-ol¡]1¡^and gibberoketosterol¡]9¡^. The structures of 1-12 were elucidated on the basis of extensive spectroscopic analysis, including IR, MS, 1D, and 2D NMR. Cytotoxicities of 1-12 against a limited panel of cancer cell lines were also evaluated. Among these metablites, compounds 9 and 11 were found to exhibit moderate cytotoxicity toward MCF-7, A549, MDA-MB-231, and HepG2 tumor cells. The ability of 9 and 10 to inhibit the pro-inflammatory iNOS and COX-2 expression of LPS-stimulated RAW264.7 macrophage cells has been also estimated.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0731106-175154 |
| Date | 31 July 2006 |
| Creators | Hsieh, Ya-ting |
| Contributors | Jhy-Horng Sheu, Ping-Jyun Sung, Chang-Yih Duh |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0731106-175154 |
| Rights | off_campus_withheld, Copyright information available at source archive |
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