The syntheses of nocardicin analogues 31, 52 and cephalosporin analogue 95 are described. None of the above compounds showed the significant antibacterial activity. / The reaction of azidoacetyl chloride with various Schiff bases derived from phenylpropargyl aldehyde and substituted anilines, afforded (beta)-lactams in fair to good yields. / A new bicyclic (beta)-lactam 162 was synthesized. The key step involved the phosphorylation of the nitrogen on an N-unsubstituted (beta)-lactam ring. / A key intermediate 188 for the synthesis of monobactam analogue has been prepared.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.68713 |
| Date | January 1981 |
| Creators | Liu, Whi-Yu. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Chemistry) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000139378, proquestno: AAINL10269, Theses scanned by UMI/ProQuest. |
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