Lactase persistence (LP) is a genetically determined trate caused by the expression of lactase in adulthood. Lactase is the intestinal enzyme responsible for digestion of milk sugar, lactose. Its production in the small intestine decreases during the childhood, this physiological condition is called lactose intolerance. However, in some individuals production of this enzyme is not stopped. The persistence of lactase activity is a recent phenomenon, which arose independently in several parts of the world over the past roughly 10,000 years, in connection with the emergence of agriculture, specifically milk production and is (likely) still under strong selection pressure. LP was first observed in Europe, where it is associated with a mutation -13 910*T. Frequency of this mutation correlates with latitude. In Africa, the presence of LP is conversely associated with herding and falls under the hypothesis of genetic and cultural co-evolution associated with cattle and the use of secondary food sources. Pastoral populations living in different areas of Africa have different LP mutations that are linked to their origin. Although many investigation on LP have already been carried out, neither analysed the Tuareg populations. This study is focused on the analysis LP mutations in 93 samples of Tuaregs from...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:351426 |
| Date | January 2016 |
| Creators | Šmídková, Lucie |
| Contributors | Černý, Viktor, Brůžek, Jaroslav |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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