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Molecular and Circuit Mechanisms of Insulin Signaling in Caenorhabditis elegans

Insulin signaling is highly conserved across animals, and is known for its ubiquitous function in all aspects of animal physiology. Despite its relatively well-studied role in metabolism and energy expenditure, how it is involved in learning and memory remains a mystery, due to the complex nature of the nervous system. In this thesis, I have used C. elegans, a tractable model organism with a sophisticated behavioral repertoire, to investigate molecular and cellular mechanisms of insulin signaling in learning.

Identiferoai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/11744446
Date January 2014
CreatorsChen, Zhunan
ContributorsZhang, Yun
PublisherHarvard University
Source SetsHarvard University
Languageen_US
Detected LanguageEnglish
TypeThesis or Dissertation
Rightsclosed access

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