Indiana University-Purdue University Indianapolis (IUPUI) / This study attempted to identify the incomplete
manifestations of gene(s) producing cleft lip and/or
cleft palate. An effort was made to determine how
various oral-facial discrepancies, when considered as
incomplete manifestations of clefting, might produce
an obvious mode of inheritance of the clefting trait
i n families with a history of cleft lip and/or cleft
palate. Eleven families were studied, selection being
made on the basis of the degree of relationship of the
affected individuals to the proband.
Oral and facial discrepancies including bifid uvula,
mandibular lip pits, commissural lip pits, raphe of the
upper lip, notching of the alveolus, asymmetrical nasal
shape, congenitally missing and malformed maxillary
central and lateral incisors, and excessive crowding of
the teeth in the anterior segment of the maxillary arch
were selected as possible incomplete manifestations of
gene action. The results of this study demonstrated that
when these manifestations were considered together with
the cleft lip and/or cleft palate condition, no additional
information on the manner of inheritance of the cleft lip
and/or cleft palate trait was produced.
Ocular and orbital measurements, which may also
be used in determining possible mid-facial discrepancies,
were compared between the relatives of families with a
history of clefting and a control group of individuals
ranging from four to 22 years of age. A total of 166
individuals were compared. Significant differences in
the circumference-interorbital index, skeletal interorbital
distance, and the canthal index were found.
Since these significant differences in the ocular
and orbital measurements could not be significantly
related to the degree of relationship between affecteds
(the test of heritability), they should be held with
some reservation until a larger sample can be studied.
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/3671 |
| Date | January 1966 |
| Creators | Coccia, Chester Tullio, 1935- |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
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