The effect of vitamin B-6 (B-6) status on plasma fatty acids (FA) levels and lipid
metabolism was investigated in this metabolic study. Eight female subjects were fed for 28
days. For the first 7 days, they were fed a constant diet containing 2.10 mg of B-6. For the
rest of the period (21 days), they were differentiated in terms of B-6 intake; 4 of them
were fed a low (0.93 mg/day) and 4 a high (2.60 mg/day) B-6 diet. B-6 status indices,
plasma FA concentration and lipid profile were determined.
Plasma pyridoxal 5'-phosphate and total B-6 concentration (P<0.01), urinary 4-
pyridoxic acid and total B-6 concentration (P<0.001) showed a significant difference
between the two groups at the end of the study. Erythrocyte PLP failed to show any
significant difference between the two groups throughout the diet study.
There was no significant difference in the plasma FA or lipid profile between the
two groups. Plasma total cholesterol (TC) of the low B-6 group decreased slightly (7 %),
but was not statistically significant. When comparing day 7 and day 28 values, plasma
triglycerides increased (9 %) for the high and decreased for the low B-6 group. LDL-C
decreased (5 %) for the high B-6 group but did not change in the low B-6 group. HDL-C
decreased slightly in both groups (~8 %).
There was no clear evidence that a low intake of vitamin B-6 affects the fatty acid
and lipid metabolism. Further studies are required to identify the relationship between
vitamin B-6 and fatty acid and lipid metabolism in humans. / Graduation date: 1997
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27444 |
| Date | 08 May 1997 |
| Creators | Kim, Min Sun, 1971- |
| Contributors | Leklem, James E. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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