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LDL receptor regulation in human liver cells by dietary fatty acids and antioxidants : a thesis presented for the Degree of Doctor of Philosophy at the University of Adelaide / Sebely Pal.

Erratum final three leaves of thesis. / Includes bibliographical references (leaves 266-288). / xvi, 288, [3] leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Demonstrates that fatty acids and antioxidants can regulate the low density lipoprotein (LDL) receptor at the level of gene transcription in cultured liver cells. EPA and linoleic acid (PUFAs) are specifically shown to downregulate the LDL receptor compared to saturated and monosaturated fatty acids in the presence or absence of cholesterol. The experiments lead to the discovery that antioxidants can upregulate the LDL receptor in the human HepG2 cells. / Thesis (Ph.D.)--University of Adelaide, Dept. of Animal Science, 1996

Identiferoai:union.ndltd.org:ADTP/260172
Date January 1996
CreatorsPal, Sebely, 1965-
Source SetsAustraliasian Digital Theses Program
Languageen_US
Detected LanguageEnglish

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