Using second trimester amniotic fluid (AF), the objectives of this study were two-fold: 1) to investigate the relationship between AF glucose and insulin levels as a predictor of macrosomia and 2) to create a risk profile for macrosomia (LGA> 90th percentile) using a combination of AF glucose and insulin concentrations. Amniotic fluid samples were obtained from non-diabetic women (n = 542) undergoing age-related amniocentesis (12th to 22nd week). AF glucose was quantified using a standard hexokinase assay and AF insulin was quantified using the Beckman Access ultrasensitive assay system. Although LGA infants were found to have significantly higher concentrations of insulin and glucose in their 2nd trimester AF, logistic regressions showed that neither alone predicted the outcome of macrosomia. However, a Bayesian two-dimensional contour map plotted the risk for LGA using both AF glucose and insulin. The two-dimensional contour map illustrated the value in considering AF glucose and insulin together to predict LGA in newborns.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.111582 |
| Date | January 2008 |
| Creators | Rubino, Maria. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (School of Dietetics and Human Nutrition.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 003164458, proquestno: AAIMR66885, Theses scanned by UMI/ProQuest. |
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