No / The ability of a cell to contract plays an important role in determining the ability of the cell to migrate, proliferate
and associating with other cells. The transduction of the force in soft substrate such as the liquid crystal surface is a method
proposed to study the traction forces of single cells. In this work, finite element method was used to study the compressive
forces induced by the keratinocyte to the liquid crystal surface via the anchorage of focal contacts. The constitutive finite
element model of the liquid crystal-focal contacts was established. The stress and displacement were analyzed using linear
static stress analysis for a quiescent cell. The data for lateral displacements obtained from the experiment were provided as
inputs to develop the model and verified through the output acquired for both simulation and experiment. The simulation
results indicated that the cell compressive stresses were in the range of 14.93 ± 1.9 nN/μm2
per focal contact. Based on the
result obtained, it was suggested to model focal contact-liquid crystal interface with a compressive model that can better
approximate the mechanism observed
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/9226 |
| Date | January 2015 |
| Creators | Soon, Chin Fhong, Tee, K.S., Youseffi, Mansour, Denyer, Morgan C.T. |
| Source Sets | Bradford Scholars |
| Detected Language | English |
| Type | Article, No full-text available in the repository |
| Relation | http://www.arpnjournals.org/jeas/research_papers/rp_2015/jeas_1015_2747.pdf |
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