Introduction: Using an animal model, we examined weight gain in rats exposed to olanzapine, as well as whether increased weight was associated with food intake, visceral fat and/or locomotion. Methods: Sprague-Dawley rats were chronically treated with olanzapine while being offered diets including standard chow, a high fat (60% fat) diet, and a high fat/high carbohydrate (42% fat; 42.7% carbohydrate) diet. Body weight, food intake, visceral fat and locomotor activity were measured. Results: Our findings related to weight gain are in line with other reports indicating that while olanzapine-induced weight gain can be observed, it does not mirror what is observed in humans on two levels: (i) it is not of the same magnitude, and (ii) it is more gender specific i.e., females greater than males. Conclusions: These data confirm that chronic treatment with olanzapine has varying effects on weight gain, food intake, visceral fat and locomotor activity.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/18900 |
| Date | 15 February 2010 |
| Creators | Mann, Stephen Wallace |
| Contributors | Remington, Gary |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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