A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine. / Pulmonary complications including acute chest syndrome are
leading causes of sickle cell disease related morbidity and
mortality. Studies have shown that pulmonary changes can be
detected during childhood. Spirometry is the current standard
for measuring lung function. Growing evidence suggests that
lung clearance index (LCI) is as sensitive as spirometry in
identifying pulmonary changes in pediatric patients.
Our cross-sectional study compared the sensitivity of LCI to
spirometry in the detection of early pulmonary changes in
children with sickle cell disease. Our results show that LCI
significantly correlates to FEV1% predicted (Spearman’s
coefficient -0.44, p = 0.003), FVC % predicted (Spearman’s
coefficient -0.44, p = 0.006) and FEF25-75 (Spearman’s
coefficient -0.49, p <0.001).
Using receiver operating characteristic (ROC) curves, LCI was
found to be more sensitive than spirometry, but less specific.
The data support LCI’s use as a test to screen for pulmonary
changes in children with sickle cell disease. Earlier monitoring
of lung function will allow for preventative therapies and delayed progression of pulmonary dysfunction.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/627163 |
| Date | 30 March 2018 |
| Creators | Chaung, Monica |
| Contributors | The University of Arizona College of Medicine - Phoenix, Williams, Sophia MD, MPH |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
| Rights | Copyright © is held by the author. Digital access to this material is made possible by the College of Medicine - Phoenix, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
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